diff --git a/ports/nrf/nrfx_config.h b/ports/nrf/nrfx_config.h
index e37c60934..a13ddf018 100644
--- a/ports/nrf/nrfx_config.h
+++ b/ports/nrf/nrfx_config.h
@@ -31,8 +31,8 @@
 #define CIRCUITPY_NRF_NUM_I2C 2
 #endif
 
-#if CIRCUITPY_NRF_NUM_I2C != 1 && CIRCUITPY_NRF_NUM_I2C != 2
-# error CIRCUITPY_NRF_NUM_I2C must be 1 or 2
+#if CIRCUITPY_NRF_NUM_I2C != 0 && CIRCUITPY_NRF_NUM_I2C != 1 && CIRCUITPY_NRF_NUM_I2C != 2
+# error CIRCUITPY_NRF_NUM_I2C must be 0, 1, or 2
 #endif
 
 // Enable SPIM1, SPIM2 and SPIM3 (if available)
@@ -44,7 +44,7 @@
 #ifdef NRF52840_XXAA
     #define NRFX_SPIM_EXTENDED_ENABLED 1
     #define NRFX_SPIM3_ENABLED 1
-#else
+#elif CIRCUITPY_NRF_NUM_I2C == 2
     #define NRFX_SPIM3_ENABLED 0
 #endif
 
@@ -56,17 +56,18 @@
 #define NRFX_QSPI_ENABLED                          1
 
 // TWI aka. I2C; always enable TWIM0 (no conflict with SPIM1 and SPIM2)
+#if CIRCUITPY_NRF_NUM_I2C == 1 || CIRCUITPY_NRF_NUM_I2C == 2
 #define NRFX_TWIM_ENABLED 1
 #define NRFX_TWIM0_ENABLED 1
+#define NRFX_TWIM_DEFAULT_CONFIG_IRQ_PRIORITY 7
+#define NRFX_TWIM_DEFAULT_CONFIG_FREQUENCY NRF_TWIM_FREQ_400K
+#define NRFX_TWIM_DEFAULT_CONFIG_HOLD_BUS_UNINIT 0
+#endif
 
 #if CIRCUITPY_NRF_NUM_I2C == 2
 #define NRFX_TWIM1_ENABLED 1
 #endif
 
-#define NRFX_TWIM_DEFAULT_CONFIG_IRQ_PRIORITY 7
-#define NRFX_TWIM_DEFAULT_CONFIG_FREQUENCY NRF_TWIM_FREQ_400K
-#define NRFX_TWIM_DEFAULT_CONFIG_HOLD_BUS_UNINIT 0
-
 // UART
 #define NRFX_UARTE_ENABLED 1
 #define NRFX_UARTE0_ENABLED 1
diff --git a/ports/nrf/supervisor/port.c b/ports/nrf/supervisor/port.c
index 1b92e7832..3f16e090f 100644
--- a/ports/nrf/supervisor/port.c
+++ b/ports/nrf/supervisor/port.c
@@ -101,9 +101,11 @@ void reset_port(void) {
     gamepad_reset();
 #endif
 
+#if CIRCUITPY_BUSIO
     i2c_reset();
     spi_reset();
     uart_reset();
+#endif
 
 #if CIRCUITPY_NEOPIXEL_WRITE
     neopixel_write_reset();